Probabilistic structure learning for eegmeg source imaging with hierarchical graph prior feng liu, li wang y, yifei lou, rencang li, patrick l. They used an automated spike classification and subsequently projected the eeg in the source space on an equivalent current dipole with. Derived from standard eeg high density caps, esi provides functional images of the whole brain with an exquisite temporal resolution. Katrina w endel,1outi v ais anen,1jaakko malmivuo,1nevzat g. Eeg source imaging in epilepsypracticalities and pitfalls. Using sophisticated source and head models, the location of the generators that gave rise to the scalp potential map can be estimated with high reliability and reasonable precision. We discuss 1 the number and positioning of electrodes, 2 the varieties of inverse solution models and algorithms, 3 the integration of eeg source estimations with mri data, 4 the integration of time and frequency in source imaging, and 5 the statistical analysis of inverse solution results. Relating measures of electroencephalography eeg back to the underlying sources is a longstanding inverse problem.
Toward an understanding of dynamic cognitive processes thinhnguyen, 1 thomaspotter, 1 tracnguyen, 1 christofkarmonik, 2 robertgrossman, 3 andyingchunzhang 1,4 department of biomedical engineering, cullen college of engineering, university of houston, houston, tx, usa. Subcortical electrophysiological activity is detectable with. This chapter describes methods to analyze the scalp electric field recorded with multichannel electroencephalography eeg. Fast oscillations fo are a promising biomarker of the epileptogenic zone ez in the intracranial electroencephalogram eeg. The ultimate goal of modern eeg source imaging is the localization of the eeg sources in anatomically defined brain structures so that direct comparison with other imaging methods, with lesion studies, or with intracranial recordings can be made. Effects of forward model errors on eeg source localization. Validating noninvasive eeg source imaging using optimal. Probabilistic structure learning for eegmeg source imaging with. We present the four key areas of researchpreprocessing, the volume conductor, the forward problem, and the inverse problem that affect the performance of eeg and meg source imaging. Pitfalls in the dipolar model for the neocortical eeg sources. The esi techniques have been used in several clinical andor brain research applications such as the study of language mechanisms, cognition process and sensory function.
Leadfield bases for electroencephalography source imaging. Towards the utilization of eeg as a brain imaging tool. Most centers perform videoeeg monitoring, mri and interictal pet, but do not perform eeg source imaging to localize the epileptogenic zone. Eeg source imaging esi, motor imagery mi, neuroimaging. This is an illposed problem due to the nonuniqueness of the solution and regularization or prior information is needed to undertake electrophysiology source imaging. Most centers perform video eeg monitoring, mri and interictal pet, but do not perform eeg source imaging to localize the epileptogenic zone.
Approximate average head models for eeg source imaging. Therefore, eeg source imaging is a prerequisite for functional connectivity analysis for a recent tutorial paper on eeg connectivity measures see. In contrast, source localization on realistic head models remains slow, with subcentimeter accuracy being the exception rather than the norm. Despite increasing use, the diagnostic yield of msi is uncertain, with reports varying from 5% to 35%. Structured sparsity priors can be attained through combinations of l1 normbased and l2 normbased constraints such as the elastic. Eeg source imaging of brain states using spatiotemporal regression. Eeglab features processing source activity isolated using ica.
The proposed spatiotemporal fmri constrained eeg source imaging approach utilizes the eeg data in a selected time window to determine the bestfit source prior from the fmri bold activation map. Eeg source imaging esi is a modelbased imaging technique that integrates temporal and spatial components of eeg to identify the generating source. Murray a,c, a eeg brain mapping core, center for biomedical imaging of lausanne and geneva, switzerland. Today, eeg is accepted as a powerful tool to capture brain function with the unique advantage of measuring neuronal processes in the time frame in which these processes occur, namely in the subsecond range. Brain topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including eeg, meg, fmri, tms, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Source localization on simple spherical models has become increasingly efficient, with consistently reported accuracy of within 5 mm. We present the four key areas of researchpreprocessing, the volume conductor, the forward problem, and the inverse problemthat affect the performance of eeg and meg source imaging. We analyzed highdensity eeg recordings of 10 focal drugresistant. A unied bayesian framework for megeeg source imaging david wipf and srikantan nagarajan biomagnetic imaging lab, university of california, san francisco 5 parnassus avenue, s362 san francisco, ca 94143 usa phone. Submissions combining multiple techniques are particularly.
This is the first study that assesses if electrical source imaging of fo using 256channel highdensity eeg is feasible and useful for ez identification. Review towards the utilization of eeg as a brain imaging tool christoph m. Probabilistic structure learning for eegmeg source. To compare eeg source imaging results with the actual dbs electrode positions, identified from postop computer tomography ct, we spatially aligned imaging data from these different modalities. With advances in highdensity eeg, systems now allow fast and easy recording from 64 to 256 channels simultaneously. We show that modern eeg source imaging simultaneously details the temporal and spatial dimensions of. Research article eeg source imaging guided by spatiotemporal specific fmri. Other eeg source imaging software may apply similar or different approaches to the different.
However, it is generally stated that eeg suffers from a poor spatial. Electroencephalography eeg is an electrophysiological monitoring method to record electrical activity of the brain. Fourth, eeg mapping is the precursor for eeg source imaging. Eeg source imaging esi is a modelbased imaging technique that integrates temporal and spatial components of eeg to identify the generating source of electrical potentials recorded on the scalp.
The information about how the different steps are performed in cartool is only meant as a suggestion. Probabilistic structure learning for eegmeg source imaging. In this post, we discuss the added value of the different techniques and the advantages of including eeg source localization during. A standardized source imaging procedure constrained to the individual gray matter was applied to the averaged spikes of each patient. Recent development in brain source imaging has offered more exciting options to localize brain sources from scalp eeg signals and have largely. The resulting fmri priors are in turn utilized in fmriinformed eeg source localization in order to solve the timing mismatch between eeg and fmri. Brain source imaging is an important method for noninvasively characterizing brain activity using electroencephalogram eeg or. Eeg source imaging guided by spatiotemporal specific fmri. The university of chicago illinois meg center alexian brothers medical center.
Eeg source imaging aai scientific cultural services. On the other hand, deriving the eegmeg signals for a known source configuration is referred to as the. The pros and cons of eeg and meg source imaging 1262011 john s. We conclude that combining eeg source imaging with other complementary modalities is a promising. In 32 patients, the presurgical workup identified a focal epileptogenic area. We show that modern eeg source imaging simultaneously details the. In recent years, significant progress has been made in the area of electroencephalography eeg source imaging. Patternrecognition algorithms can characterize the topography of scalp electric fields and detect changes in topography over time and between. We show that modern eeg source imaging simultaneously details the temporal and spatial dimensions of brain activity, making it an important and affordable tool to study the properties of cerebral.
Supervised discriminative eeg brain source imaging with graph regularization 3 3 proposed framework 3. The estimation of eeg generating sources constitutes an inverse problem ip in neuroscience. The 128channel eeg source imaging correctly localized this area in 30 of these patients 93. Approximate average head models for eeg source imaging pedro a. Magnetic source imaging msi is used routinely in epilepsy presurgical evaluation and in mapping eloquent cortex for surgery.
We show that modern eeg source imaging simultaneously details the temporal and spatial dimensions of brain activity, making it an important and affordable tool to study the properties of cerebral neural networks in cognitive and clinical neurosciences. We show that modern eeg source imaging simultaneously details the temporal and spatial dimensions of brain activity, making it. Scalp electroencephalographic eeg electrodes record sums of activity from cortical sources and nonbrain processes, making direct interpretation of scalp channel waveforms problematic. It is typically noninvasive, with the electrodes placed along the scalp, although invasive electrodes are sometimes used, as in electrocorticography. Towards standardized eeg source imaging in the presurgical. White matter architecture rather than cortical surface area correlates with the eeg alpha rhythm. The combination of eeg source imaging and eegcorrelated. Eeg source imaging of brain states using spatiotemporal. An in vivo mri template set for morphometry, tissue segmentation, and fmri localization in. Eeg recorded during resting was compared between qigong meditators and controls. Eeg measures voltage fluctuations resulting from ionic current within the neurons of the brain. A unied bayesian framework for megeeg source imaging.
Methods we prospectively recorded magnetoencephalography meg simultaneously with eeg and performed emsi, comprising electric source imaging, magnetic source imaging, and analysis of combined megeeg datasets, using. Purdon june 7, 2019 abstract brain source imaging is an important method for noninvasively charac. To compare eeg source imaging results with the actual dbs electrode positions, identified from postop computer tomography ct, we spatially. In addition, we evaluated the effect of the number of electrodes on localization precision, i. Cortical surface alignment in multisubject spatiotemporal independent eeg source imaging arthur c. Electromagnetic source imaging in presurgical workup of. Using loreta low resolution electromagnetic tomography to compute the intracerebral source locations, differences in brain activations between groups.
Forward modeling forward modeling is a decisive stage in source imaging, as it substantially influences the accuracy of eeg source localization results. Frontiers spatio temporal eeg source imaging with the. Tsai1, tzyyping jung2,3, vincent chien1, alexander n. The intracerebral localization of brain electric activity during the two meditation conditions was compared using sloreta functional eeg tomography. Supervised discriminative eeg brain source imaging with. Research article eeg source imaging guided by spatiotemporal. Solving a forward problem relates the cortical sources to the sensorspace eeg. Qigong were studied with multichannel eeg source imaging during their meditations. In this post, we discuss the added value of the different techniques and the advantages of including eeg source localization during phase 1 in your presurgical workup. In each key area we identify prominent approaches and methodologies that have open issues warranting further investigation within the community, challenges associated with certain techniques, and algorithms. Esi has been used to determine important features of neuronal connectivity in autism spectrum disorders coben. Cortical surface alignment in multisubject spatiotemporal.1494 962 848 645 847 1574 1015 173 1099 841 906 609 1469 59 807 581 461 302 1139 298 683 290 504 158 492 652 1636 1011 209 846 931 1530 613 533 887 45 71 1458 285 1015 1394 17 453 534 26